paired box protein PAX4 (PAX4)

Function

• role in the differentiation & development of pancreatic islet beta cells
• transcriptional repressor that binds to a common element in the glucagon, insulin & somatostatin promoters
• competes with PAX6 for this same promoter binding site
• Pax4v isoform appears to be a dominant negative form antagonizing PAX4 transcriptional activity

Structure

• belongs to the paired homeobox family
• contains 1 homeobox DNA-binding domain
• contains 1 paired domain

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• paired box protein (PAX)

Database

• UniProt: http://www.uniprot.org/uniprot/O43316.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5078
• OMIM: https://mirror.omim.org/entry/167413
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5078