early growth response protein 2; EGR-2; protein Krox-20; AT591 (EGR2, KROX20)
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Function
- sequence-specific DNA-binding transcription factor
- binds to two specific DNA sites located in the promoter region of HOXA4 gene
- interacts with HCFC1
Structure
- belongs to the EGR C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment
Alternative splicing
named isoforms=2
Pathology
- defects in EGR2 are a cause of:
More general terms
References
- ↑ Herschman HR Extracellular signals, transcriptional responses and cellular specificity TIBS 14:455 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2696174
- ↑ Gashler A and Sukhatme VP Early growth response protein 1 (EGR-1): prototype of a zinc- finger family of transcription factors. Prog Nuclei Acid Res Mol Biol 1995, 50:191 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7754034
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1959
- ↑ Inherited peripheral neuropathies mutation db http://www.molgen.ua.ac.be/CMTmutations/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=EGR2
- ↑ UniProt http://www.uniprot.org/uniprot/P11161.html
Database
- UniProt: http://www.uniprot.org/uniprot/P11161.html
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1959
- OMIM: https://mirror.omim.org/entry/129010
- OMIM: https://mirror.omim.org/entry/145900
- OMIM: https://mirror.omim.org/entry/605253
- OMIM: https://mirror.omim.org/entry/607678
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1959