homeobox protein HOX-A4; Hox-1D; Hox-1.4 (HOXA4, HOX1D)

Function

• sequence-specific transcription factor
• part of a developmental regulatory system that provides cells with specific positional identities on the anterior- posterior axis
• binds to sites in the 5'-flanking sequence of its coding region with various affinities
• consensus sequences of the high & low affinity binding sites are 5'-TAATGA[CG]-3' & 5'-CTAATTTT-3'

Structure

• belongs to the antp homeobox family, deformed subfamily
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Expression

embryonic nervous system

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q00056.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3201
• OMIM: https://mirror.omim.org/entry/142953
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3201