early growth response protein 1; EGR-1; protein Krox-24, transcription factor Zif268; nerve growth factor-induced protein A; NGFI-A; transcription factor ETR103; zinc finger protein 225; AT225 (EGR1, ZNF225)
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Function
- transcriptional regulator
- recognizes & binds to the DNA sequence 5'-CGCCCCCGC-3' (EGR-site)
- activates transcription of target genes whose products are required for mitogenesis & differentiation
Structure
- belongs to the EGR C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment
Expression
induced by growth factors
More general terms
Additional terms
References
- ↑ Herschman HR Extracellular signals, transcriptional responses and cellular specificity TIBS 14:455 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2696174
- ↑ Gashler A and Sukhatme VP Early growth response protein 1 (EGR-1): prototype of a zinc- finger family of transcription factors. Prog Nuclei Acid Res Mol Biol 1995, 50:191 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7754034
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1958
- ↑ UniProt http://www.uniprot.org/uniprot/P18146.html