nuclear factor 1 X-type (nuclear factor 1/X, NF1-X, NFI-X, NF-I/X, CCAAT-box-binding transcription factor, CTF, TGGCA-binding protein, NFIX)

Function

• recognizes & binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral & cellular promoters
• capable of activating transcriptio
• binds DNA as homodimer

Structure

• contains 1 CTF/NF-I DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=5

Pathology

• binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral promoters & in the origin of replication of adenovirus type 2
• capable of activating transcription & replication

More general terms

• nuclear factor 1

Database

• OMIM: https://mirror.omim.org/entry/164005
• UniProt: http://www.uniprot.org/uniprot/Q14938.html