nuclear factor 1 C-type; NF1-C; nuclear factor 1/C; CCAAT-box-binding transcription factor; CTF; nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein (NFIC, NFI)

Function

• recognizes & binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral & cellular promoters & in the origin of replication of adenovirus type 2
• these proteins are individually capable of activating transcription & replication
• binds DNA as a homodimer

Structure

• belongs to the CTF/NF-I family
• contains 1 CTF/NF-I DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=5

More general terms

• nuclear factor 1
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4782
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4782
• OMIM: https://mirror.omim.org/entry/600729
• UniProt: http://www.uniprot.org/uniprot/P08651.html