fer3-like protein (nephew of atonal 3, basic helix-loop-helix protein N-twist, neuronal twist, FERD3L, NATO3, NTWIST)

Function

• transcription factor
• binds to the E-box
• functions as inhibitor of transcription
• DNA binding requires dimerization with an E protein
• inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (putative)
• heterodimer with TCF3/E12
• interacts with the bHLH domain of TCF3/E12 (putative)

Structure

contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus (putative)

More general terms

• basic helix loop helix (bHLH) family transcription factor
• transcriptional silencer (transcriptional repressor)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2228
• UniProt: http://www.uniprot.org/uniprot/Q96RJ6.html