Krueppel-like factor 12; transcriptional repressor AP-2rep (KLF12, AP2REP, HSPC122)

Function

• confers strong transcriptional repression to the AP2-alpha gene
• binds to a regulatory element (A32) in the AP2-alpha gene promoter

Structure

• belongs to the Sp1 C2H2-type Zn+2-finger protein family
• contains 3 C2H2-type Zn+2 fingers

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• Krueppel-like factor
• transcriptional silencer (transcriptional repressor)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11278
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11278
• OMIM: https://mirror.omim.org/entry/607531
• UniProt: http://www.uniprot.org/uniprot/Q9Y4X4.html