transducin-like enhancer protein 6 (TLE6)

Function

• transcriptional corepressor that binds to a number of transcription factors
• inhibits transcriptional activation mediated by CTNNB1 & TCF family members in Wnt signaling
• effects of full-length TLE family members may be modulated by association with dominant-negative AES
• homooligomer & heterooligomer with other family members

Structure

• belongs to the WD repeat Groucho/TLE family
• contains 7 WD repeats

Compartment

nucleus

More general terms

• transcriptional silencer (transcriptional repressor)
• transducin-like enhancer protein (ESG)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H808.html