Fez family zinc finger protein 2 (forebrain embryonic zinc finger-like protein 2, zinc finger protein Fez-like, zinc finger protein 312, FEZF2, FEZL, ZNF312, FKSG36)

Function

• transcription repressor
• required for specification of corticospinal motor neurons & other subcerebral projection neurons
• may play a role in layer & neuronal subtype-specific patterning of subcortical projections & axonal fasciculation
• controls development of dendritic arborization & spines of large layer V pyramidal neurons
• may be involved in innate immunity

Structure

• belongs to the krueppel C2H2-type zinc-finger protein family
• contains 6 C2H2-type zinc fingers

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• C2H2 type zinc finger protein
• transcriptional silencer (transcriptional repressor)

Database

• OMIM: https://mirror.omim.org/entry/607414
• UniProt: http://www.uniprot.org/uniprot/Q8TBJ5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=94016