C-myc promoter-binding protein (DENN domain-containing protein 4A, DENND4A, IRLB, MYCPBP)

Function

• binds to ISRE-like element* of MYC P2 promoter

* interferon-stimulated response element

Structure

• contains 1 dDENN domain
• contains 1 DENN domain
• contains 2 PPR repeats (pentatricopeptide repeats)
• contains 1 uDENN domain

Compartment

nucleus

Expression

• ubiquitous
• expressed in bone marrow > peripheral blood lymphocytes > spleen
• expression is growth- & cell cycle-dependent
• highly expressed in fetal liver
• induced by serum in low-passage fibroblasts

Pathology

• in brain, breast & prostate expression higher in normal cells than in tumor cells

More general terms

• DNA-binding protein
• transcriptional silencer (transcriptional repressor)

Additional terms

• enolase-1; alpha enolase; phosphopyruvate hydratase; C-myc promoter-binding protein; plasminogen-binding protein (ENO1, ENO1L1, MBPB1, MPB1)

Database

• OMIM: https://mirror.omim.org/entry/600382
• UniProt: http://www.uniprot.org/uniprot/Q7Z401.html