transcriptional repressor scratch 1; Scratch homolog 1 zinc finger protein; SCRT; Scratch 1; hScrt (SCRT1)

Function

• transcriptional repressor
• binds E-box motif CAGGTG
• can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation

Structure

• the N-terminal non Zn+2-finger region mediates the repressor activity
• belongs to the snail C2H2-type Zn+2-finger protein family
• contains 5 C2H2-type Zn+2 fingers

Compartment

nucleus

Expression

brain specific

More general terms

• transcriptional silencer (transcriptional repressor)
• C2H2 type zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83482
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83482
• OMIM: https://mirror.omim.org/entry/605858
• UniProt: http://www.uniprot.org/uniprot/Q9BWW7.html