phospholipid-transporting ATPase 5A; ATPase class 5 type 10A; aminophospholipid translocase VA (ATP10A, ATP10C, ATPVA, ATPVC, KIAA0566)

Function

• role in the transport of phospholipids from the outer to the inner leaflet of various membranes & the maintenance of asymmetric distribution of phospholipids
• phosphorylated upon DNA damage, probably by ATM or ATR

ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(out)

Structure

• belongs to the cation transport ATPase (P-type) (TC 3.A.3) family, type IV subfamily

Compartment

membrane

Expression

• widely expressed
• highest expression in kidney
• lesser expression in lung, brain, prostate, testis, ovary & small intestine

Pathology

• defects in ATP10A are a cause of Angelman syndrome

Genetics

• role of ATP10A in Angelman syndrome would suggest that the gene for ATP10A is an imprinted gene

More general terms

• phospholipid-transporting ATPase
• E1-E2 ATPase or P-type ATPase
• phosphoprotein

Additional terms

• molybdenum cofactor deficiency
• sulfocysteinuria; isolated sulfite oxidase deficiency

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57194
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57194
• OMIM: https://mirror.omim.org/entry/105830
• OMIM: https://mirror.omim.org/entry/605855
• UniProt: http://www.uniprot.org/uniprot/O60312.html