imprinted gene

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Introduction

Monoallelic expression or uniparental disomy. Imprinted genes display differential expression patterns & differential replication patterns of maternal & paternal alleles. Imprinted genes appear to be embedded in large DNA domains with differential expression & replication patterns, which may provide a structural imprint of parenteral identity.

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References

  1. Rainier S, Johnson LA, Dobry CJ, Ping AJ, Grundy PE, Feinberg AP. Relaxation of imprinted genes in human cancer. Nature. 1993 Apr 22;362(6422):747-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8385745
  2. Kitsberg D, Selig S, Brandeis M, Simon I, Keshet I, Driscoll DJ, Nicholls RD, Cedar H. Allele-specific replication timing of imprinted gene regions. Nature. 1993 Jul 29;364(6436):459-63. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8332218