mitochondrial uncoupling protein 3; UCP 3 (UCP3 SLC25A9)

Function

• mitochondrial transporter protein that creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation
• as a result, energy is dissipated in the form of heat
• may play a role in the modulation of tissue respiratory control
• participates in thermogenesis & energy balance

Structure

• belongs to the mitochondrial carrier family
• contains 3 solcar repeats

Compartment

mitochondrial inner membrane

Alternative splicing

named isoforms=3

Expression

• expressed only in skeletal muscle & heart
• more expressed in glycolytic than in oxidative skeletal muscles

Pathology

• defects in UCP3 may be involved in severe obesity

More general terms

• uncoupling protein
• solute carrier family 25 (SLC25, SLC25A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7352
• OMIM: https://mirror.omim.org/entry/601665
• OMIM: https://mirror.omim.org/entry/602044
• UniProt: http://www.uniprot.org/uniprot/P55916.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7352