N-terminal EF-hand Ca+2-binding protein 3; amyloid beta A4 protein-binding family A member 2-binding protein; Nek2-interacting protein 1; neuronal Ca+2-binding protein 3; X11L-binding protein 51 (NECAB3, APBA2BP, NIP1, SYTIP2, XB51)

Function

• inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), & hence allows formation of beta-amyloid
• phosphorylated by NEK2
• interacts with the N-terminal domain of APBA2
• interacts with NEK2

Structure

• contains 1 ABM domain
• contains 1 EF-hand domain

Compartment

Golgi apparatus

Alternative splicing

• named isoforms=3
• additional isoforms seem to exist
• at least one isoform may result from intron retention

Expression

• strongly expressed in heart & skeletal muscle
• moderately in brain & pancreas

More general terms

• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=63941
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:63941
• OMIM: https://mirror.omim.org/entry/612478
• UniProt: http://www.uniprot.org/uniprot/Q96P71.html