cholesteryl ester transfer protein; lipid transfer protein I (CETP)
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Function
- exchanges cholesterol ester in HDL for triglyceride in LDL & VLDL
- may also catalyze exchange of cholesterol esters between HDL & LDL & catalyze exchange of cholesterol ester in LDL for triglyceride in VLDL[2]
Structure
Compartment
Alternative splicing
named isoforms=2
Expression
expressed by the liver & secreted in plasma
Pathology
- defects in CETP are a cause of hyperalphalipoproteinemia type 1
- defects in CETP are the cause of CETP deficiency
- deficiency in animals results in resistance to atherosclerosis [1], excess in susceptibility[3]
- VV genotype (I405V) in humans promotes longevity & is protective against cognitive decline[4][8][9]
Polymorphism
Pharmacology
- CETP inhibitors lower HDL cholesterol, but may not lower risk of cardiovascular events
More general terms
Additional terms
References
- ↑ 1.0 1.1 OMIM https://mirror.omim.org/entry/188470
- ↑ 2.0 2.1 Primary Hyperlipoproteinemias, Steiner & Shafrir (eds), McGraw Hill, NY, 1991, pg 30
- ↑ 3.0 3.1 Marotti et al Nature 364:73 1993
- ↑ 4.0 4.1 Barzilai N et al, A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology 2006, 67:2170 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17190939
- ↑ 5.0 5.1 Thompson A et al, Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels and coronary risk. JAMA 2008, 299:2777 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18560005
- ↑ SHMPD, The Singapore human mutation & polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CETP
- ↑ Wikipedia, Cholesterylester transfer protein entry http://en.wikipedia.org/wiki/Cholesterylester_transfer_protein
- ↑ 8.0 8.1 Sanders AE et al. Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia. JAMA 2010 Jan 13; 303:150 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20068209
- ↑ 9.0 9.1 Soerensen M et al Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2223486
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1071
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1071
- OMIM: https://mirror.omim.org/entry/118470
- OMIM: https://mirror.omim.org/entry/143470
- OMIM: https://mirror.omim.org/entry/607322
- UniProt: http://www.uniprot.org/uniprot/P11597.html