cation channel sperm-associated protein 2 (Catsper2, CATSPER2)

Function

• voltage-gated Ca+2 channel
• role in sperm cell hyperactivation
• controls Ca+2 entry to mediate hyperactivated motility, a step needed for sperm motility
• activated by intracellular alkalinization
• heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 & CATSPER4
• interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type Ca+2 channel activity

Structure

belongs to the cation channel sperm-associated family

Compartment

cell projection, cilium, flagellum

Alternative splicing

named isoforms=4

Expression

• testis-specific
• specifically present in the principal piece of sperm tail

Pathology

• defects in CATSPER2 are a cause of deafness-infertility syndrome

More general terms

• voltage-dependent Ca+2 channel

Database

• OMIM: https://mirror.omim.org/entry/607249
• UniProt: http://www.uniprot.org/uniprot/Q96P56.html