T-type Ca+2 channel or transient current Ca+2 channel
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Function
- T-type Ca+2 channels belong to the low-voltage activated (LVA) group
- strongly blocked by mibefradil
- a particularity of T-type Ca+2 channels is an opening at quite negative potentials & a voltage-dependent inactivation
- T-type channels serve pacemaking functions in both central neurons & cardiac nodal cells & support Ca+2 signaling in secretory cells & vascular smooth muscle
- role modulation of firing patterns of neurons during information processing
- role in cell growth processes
- activated by CaM-kinase II In response to increasing intracellular Ca+2
Structure
- alpha-1G subunit of voltage-dependent Ca+2 channel gives rise to T-type Ca+2 currents
More general terms
References
- ↑ Dubel SJ, Starr TV, Hell J, Ahlijanian MK, Enyeart JJ, Catterall WA, Snutch TP. Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel. Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):5058-62. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1317580
- ↑ Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994 Mar 3;330(9):613-22. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7905600