cation channel sperm-associated protein 4 (Catsper4, CATSPER4)

Function

• voltage-gated Ca+2 channel
• role in sperm cell hyperactivation
• controls Ca+2 entry to mediate the hyperactivated motility, a step needed for sperm motility
• activated by intracellular alkalinization
• heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 & CATSPER4
• interacts with CATSPER1

Structure

• belongs to the cation channel sperm-associated family

Compartment

• cell projection, cilium, flagellum

Alternative splicing

named isoforms=2

Expression

• testis-specific
• specifically present in the principal piece of sperm tail

More general terms

• transmembrane 6 protein
• testis-specific protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7RTX7.html