pyruvate kinase

Expression

• there are 4 isozymes of pyruvate kinase in mammals: L, R, M1 & M2
• L type is major isozyme in the liver
• R is found in red cells
• M1 is the main form in muscle, heart & brain
• M2 is found in early fetal tissues

Genetics

• L & R isoforms from same gene, by alternative splicing
• M1 & M2 isoforms from same gene, by alternative splicing

More general terms

• kinase or ATP-phosphotransferase
• oligomerizing protein
• glycolytic enzyme

More specific terms

• pyruvate kinase A-type
• pyruvate kinase L-type (pyruvate kinase R/L, PKLR)
• pyruvate kinase M-type (PKM)

Additional terms

• glycolytic pathway (glycolysis, Embden Myerhof pathway)

Database

• OMIM: https://mirror.omim.org/entry/179050