somatotropin 2; growth hormone 2; growth hormone variant; placenta-specific growth hormone; placental somatotropin (GH2)

Function

• role in growth control
• major role in stimulating body growth is to stimulate the liver & ther tissues to secrete IGF-1
• Stimulates both the differentiation & proliferation of myoblasts
• also stimulates amino acid uptake & protein synthesis in muscle & other tissues
• monomer, dimer, trimer, tetramer & pentamer, disulfide- linked or non-covalently associated, in homopolymeric & heteropolymeric combinations
• can also form a complex either with GHBP or with the alpha-2-macroglobulin complex

Structure

• belongs to the somatotropin/prolactin family

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

expressed in the placenta

More general terms

• somatotropin; growth hormone; somatropin (GH)

Additional terms

• growth hormone (somatotropin) in serum

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2689
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2689
• OMIM: https://mirror.omim.org/entry/139240
• UniProt: http://www.uniprot.org/uniprot/P01242.html