thymosin beta-4; T beta-4; Fx; contains: hematopoietic system regulatory peptide; seraspenide (TMSB4X, TB4X, THYB4, TMSB4)

Function

• role in the organization of the cytoskeleton (putative)
• binds to & sequesters actin monomers (G actin) & thus inhibits actin polymerization
• seraspenide inhibits entry of hematopoietic pluripotent stem cells into the S-phase (putative)

Structure

belongs to the thymosin beta family

Compartment

cytoplasm, cytoskeleton

Expression

• expressed in several hemopoietic cell lines & lymphoid malignant cells
• decreased levels in myeloma cells
• induced by alpha interferons
• decreased levels in THP-1 cells after treatment with recombinant interferon-lambda

More general terms

• thymosin-beta

Additional terms

• thymosin beta-4-like protein (TMSL)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7114
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7114
• OMIM: https://mirror.omim.org/entry/300159
• UniProt: http://www.uniprot.org/uniprot/P62328.html