C-C motif chemokine 23; CK-beta-8; CKB-8; macrophage inflammatory protein 3; MIP-3; myeloid progenitor inhibitory factor 1; MPIF-1; small-inducible cytokine A23 (CCL23, MIP3, MPIF1, SCYA23)

Function

• chemotactic for monocytes, resting T-cells, & neutrophils
• not chemotactic for activated lymphocytes
• inhibits proliferation of myeloid progenitor cells in colony formation assays
• can bind heparin
• binds CCR1
• CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than CCL23

Structure

• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Alternative splicing

named isoforms=2; short, long

Expression

• expressed in adult lung, liver, skeletal muscle & pancreas > fetal liver, adult bone marrow & placenta
• the short form is the major species
• the long form is detected only in very low abundance

Pathology

• CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluid from patients with rheumatoid arthritis

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6368
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6368
• OMIM: https://mirror.omim.org/entry/602494
• UniProt: http://www.uniprot.org/uniprot/P55773.html