C-X-C motif chemokine 16; scavenger receptor for phosphatidylserine & oxidized low density lipoprotein; SR-PSOX; small-inducible cytokine B16; transmembrane chemokine CXCL16 (CXCL16, SCYB16, SRPSOX, UNQ2759/PRO6714)

Function

• acts as a scavenger receptor on macrophages
• specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (putative)
• induces a strong chemotactic response
• induces Ca+2 mobilization
• binds to CXCR6/bonzo

Structure

• glycosylated
• belongs to the intercrine alpha (chemokine CxC) family

Compartment

• cell membrane; single-pass type 1 membrane protein (putative)
• secreted: also exists as a soluble form

Expression

• expressed in T-cell areas
• expressed in spleen, lymph nodes, lung, kidney, small intestine & thymus
• weak expression in heart & liver
• not expressed in brain or bone marrow

More general terms

• CXC chemokine; alpha chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=58191
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:58191
• OMIM: https://mirror.omim.org/entry/605398
• UniProt: http://www.uniprot.org/uniprot/Q9H2A7.html