cytochrome P450 26A1 (retinoic acid-metabolizing cytochrome, P450RAI, retinoic acid 4-hydroxylase, cytochrome p450 subfamily 26A polypeptide 1)

Function

• retinoic acid metabolism
• hydroxylates retinoids, including
  • all-trans-retinoic acid
  • 9-cis-retinoic acid
• catalyzes 4-hydroxylation & 18-hydroxylation of retinoic acid resulting in:
  • 4-hydroxyretinoic acid
  • 4-oxo-retinoic acid
  • 18-hydroxyretinoic acid

Compartment

membrane-bound, endoplasmic reticulum

Expression

• expressed in adult liver, heart, pituitary gland, adrenal gland, placenta & regions of the brain
• induced by retinoic acid

More general terms

• cytochrome P450

Database

• OMIM: https://mirror.omim.org/entry/602239
• UniProt: http://www.uniprot.org/uniprot/O43174.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1592