cytochrome P450 4F3 (LTB4 20-monooxygenase, LTB4 omega-hydroxylase, cytochrome P450 LTB4-omega, CYP4F3)

Function

• monooxygenase
  • O2 & NADPH-dependent omega-hydroxylation of LTB4
• LTB4 catabolism; first step

Inhibition:

• inhibited by carbon monoxide

Structure

belongs to the cytochrome P450 family

Compartment

membrane-bound, endoplasmic reticulum

Expression

expressed in neutrophils & other leukocytes

More general terms

• cytochrome P450

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4051
• OMIM: https://mirror.omim.org/entry/601270
• UniProt: http://www.uniprot.org/uniprot/Q08477.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4051