cytochrome P450 1B1 (dioxin-inducible cytochrome P450, CYPIB1)

Function

• NADPH-dependent electron transport pathway
• oxidizes a variety of structurally unrelated compounds
  • steroids, fatty acids, xenobiotics
• participates in development of the eye*

Compartment

• endoplasmic reticulum membrane
• peripheral membrane, microsome membrane

Expression

• expressed in many tissues
• induced by polycyclic aromatic hydrocarbons (PAH) & 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Pathology

* mutations associated with primary congenital glaucoma GLC3A

* mutations associated with Peters anomaly, congenital defect in the anterior chamber of the eye

Polymorphism

various CYP1B1 alleles

More general terms

• cytochrome P450

Database

• OMIM: https://mirror.omim.org/entry/601771
• OMIM: https://mirror.omim.org/entry/231300
• OMIM: https://mirror.omim.org/entry/604229
• UniProt: http://www.uniprot.org/uniprot/Q16678.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1545