thiosulfate sulfurtransferase KAT (TSTD1)

Function

thiosulfate + cyanide = sulfite + thiocyanate

Structure

contains 1 rhodanese domain

Compartment

• cytoplasm, perinuclear region
• localized around the nuclear membranes

Alternative splicing

named isoforms=4

Expression

• expressed in kidney, liver & skeletal muscle > heart, colon, thymus, spleen, placenta, lung > brain, small intestine, peripheral blood leukocytes

Pathology

• possible role in tumorgenesis
• expressed at high levels in the breast carcinoma cell lines MCF-7 & MDA-MB-468 & at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma cell line LoVo & the lung carcinoma cell line A549
• no expression in the cell lines EFO27 & HeLa, or the normal breast tissue cell lines MCF-10A & H184A1
• detected in invasive ductal carcinoma, but not in the adjacent tissues

More general terms

• transferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NFU3.html