arginyl-tRNA-protein transferase 1; arginyltransferase 1; R-transferase 1; arginine-tRNA-protein transferase 1 (ATE1)

Function

• role in post-translational conjugation of Arg to the N-terminal Asp or Glu of a protein
• arginylation is required for degradation of these proteins via ubiquitin pathway
• does not arginylate Cys
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• monomer (putative)
• belongs to the R-transferase family

Compartment

• isoform ATE1-1: nucleus (putative)
• cytoplasm (putative)
• isoform ATE1-2: cytoplasm (putative)

Alternative splicing

named isoforms=2; ATE1-1, ATE1-2

Notes

• uncertain whether Met-1 or Met-37 is the initiator

More general terms

• transferase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11101
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11101
• OMIM: https://mirror.omim.org/entry/607103
• UniProt: http://www.uniprot.org/uniprot/O95260.html