histatin-3; basic histidine-rich protein; Hst; histidine-rich protein 3; PB (HTN3, HIS2)

Function

• histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle)
• histatins also exhibit antibacterial & antifungal activities
• histatin-3 1/24 (histatin-5) is especially effective against C albicans & C neoformans, & inhibits Lys-gingipain & Arg-gingipain (rgpB) from P gingivalis
• in addition, histatin-3 1/24 is a potent inhibitor of metalloproteinases MMP2 & MMP9
• 24 proteolytic products are found in saliva

Structure

belongs to the histatin/statherin family

Compartment

• secreted by serous acinar & demilune cells

Polymorphism

• there are two alleles of HTN3, HIS2(1) & HIS2(2)

More general terms

• histatin; histidine-rich protein; post PB protein (PPB)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3347
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3347
• OMIM: https://mirror.omim.org/entry/142702
• UniProt: http://www.uniprot.org/uniprot/P15516.html