gingipain
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Pathology
- trypsin-like cysteine proteinases produced by Porphyromonas gingivalis, a major cause of adult periodontitis[1] & perhaps Alzheimer's disease[2]
- may degrade cytokines, thus downregulating host inflammatory response[3]
More general terms
References
- ↑ 1.0 1.1 Imamura T. The role of gingipains in the pathogenesis of periodontal disease. J Periodontol. 2003 Jan;74(1):111-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12593605
- ↑ 2.0 2.1 Dominy SS, Lynch C, Ermini F et al Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Science Advances 23 Jan 2019: Vol. 5, no. 1, eaau3333 http://advances.sciencemag.org/content/5/1/eaau3333.full
- ↑ 3.0 3.1 Stathopoulou PG, Benakanakere MR, Galicia JC, Kinane DF. Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. J Clin Periodontol. 2010 Jan;37(1):24-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20096064 Free PMC Article
- ↑ Wikipedia: Gingipain https://en.wikipedia.org/wiki/Gingipain