mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1, hMAdCAM-1, MADCAM1)

Function

• cell adhesion leukocyte receptor expressed by mucosal venules
• helps to direct lymphocyte traffic into mucosal tissues, including Peyer patches & intestinal lamina propria
• binds both integrin alpha-4/beta-7 & L-selectin, regulating both the passage & retention of leukocytes

Structure

• mucin-like domain may be O-glycosylated
• isoform 2 lacks the mucin-like domain
• contains 2 Ig-like (immunoglobulin-like) domains
• homodimer (putative)

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• highly expressed on high endothelial venules & lamina propia venules found in the small intestine, & to a lesser extent, in colon & spleen
• very low levels of expression found in pancreas & brain
• not expressed in thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidneys or peripheral blood leukocytes

Polymorphism

• number of repeats in the mucin domain varies from 6-8 repeats

More general terms

• adhesion receptor

Database

• OMIM: https://mirror.omim.org/entry/102670
• UniProt: http://www.uniprot.org/uniprot/Q13477.html