dedicator of cytokinesis protein 3; modifier of cell adhesion; presenilin-binding protein; PBP (DOCK3, KIAA0299, MOCA)

Function

• guanine nucleotide exchange factor (putative)
• interacts with presenilins
• stimulates MAPT (tau) phosphorylation
• regulation of actin cytoskeleton or cell adhesion receptors (putative)
• interacts with presenilins PSEN1, PSEN2, CRK

Structure

• the DHR-2 domain may mediate some GEF activity
• belongs to the DOCK family
• contains 1 DHR-1 domain
• contains 1 DHR-2 domain
• contains 1 SH3 domain

Compartment

cytoplasm

Expression

• in normal brains, localized in the neuropil, & occasionally in pyramidal cells

Pathology

• in Alzheimer disease brains, associated with neurofibrillary tangles
• chromosomal inversion inv(3)(p14:q21) involving DOCK3 & SLC9A9 associated with ADHD

More general terms

• dedicator of cytokinesis protein (DOCK)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1795
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1795
• OMIM: https://mirror.omim.org/entry/603123
• UniProt: http://www.uniprot.org/uniprot/Q8IZD9.html