Kelch-like protein 12 (CUL3-interacting protein 1, KLHL12, C3IP1)

Function

• serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex
• negatively regulates Wnt signaling pathway via targeted ubiquitination & subsequent proteolysis of DVL3
• component of ubiquitin-protein E3 ligase complex which includes CUL3 & KLHL12
  • complex interacts with DVL3 upon activation of Wnt signaling pathway by WNT3A

Structure

• BTB domain is required for interaction with CUL3 contains 1 BTB domain (POZ domain contains 6 Kelch repeats

Expression

• expressed in testis & at lower levels in submandibular salivary gland

More general terms

• kelch-like protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q53G59.html