pleckstrin homology domain-containing family A member 8 (phosphoinositol 4-phosphate adapter protein 2, phosphatidylinositol-four-phosphate adapter protein 2, hFAPP2, serologically defined breast cancer antigen NY-BR-86, PLEKHA8, FAPP2)

Function

• role in TGN-to-plasma membrane transport & in the formation of post-Golgi constitutive carriers
• may play a role in ensuring the coordination of budding & fission reactions
• interacts with phosphatidylinositol-4-phosphate (PIP) & the GTPase ADP-ribosylation factor (ARF)

Structure

• contains 1 plekstrin homology domain (PH domain)
• interacts with PIP & ARF via plekstrin homology domain

Compartment

• cytoplasm
• localized to perinuclear structures in the trans-Golgi network (TGN)

Alternative splicing

named isoforms=3

Expression

expressed in kidney cell lines

More general terms

• pleckstrin homology domain containing family

Database

• OMIM: https://mirror.omim.org/entry/608639
• UniProt: http://www.uniprot.org/uniprot/Q96JA3.html