protein fem-1 homolog C (FEM1-gamma, FEM1c, FEM1C, KIAA1785)

Function

• probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit component of some E3 ubiquitin-protein ligase complex protein degradation; protein ubiquitination

Structure

• belongs to the fem-1 family
• contains 9 ANK repeats
• contains 2 TPR repeats

Compartment

cytoplasm (putative)

Expression

• widely expressed
• highly expressed in kidney, cardiac tissue, skeletal muscle & testis
• expressed at lower levels in other tissues, including cartilage

Notes

Was initially thought to be the ortholog of mouse FEM1A

More general terms

• ankyrin repeat domain protein (ANKRD)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5692
• OMIM: https://mirror.omim.org/entry/608767
• UniProt: http://www.uniprot.org/uniprot/Q96JP0.html