GTPase ERas (E-Ras, embryonic stem cell-expressed Ras, v-Ha-ras Harvey rat sarcoma viral oncogene homolog 2, ERAS, HRAS2, HRASP)

Function

• GTPase
• role in tumor-like growth properties of embryonic stem cells
• alternates between an inactive form bound to GDP & an active form bound to GTP
• activated by a guanine nucleotide-exchange factor (GEF) & inactivated by a GTPase-activating protein (GAP)
• interacts with PIK3CD

Structure

• belongs to the small GTPase superfamily, Ras family

Compartment

cell membrane, lipid-anchor, cytoplasmic side

More general terms

• ras subfamily protein

Database

• OMIM: https://mirror.omim.org/entry/300437
• UniProt: http://www.uniprot.org/uniprot/Q7Z444.html