RNA-binding motif protein, Y chromosome, family 1 member A1/C; RNA-binding motif protein 1; RNA-binding motif protein 2; Y chromosome RNA recognition motif 1; hRBMY (RBMY1A1, RBM1, RBM2, YRRM1)

Function

• RNA-binding protein
• may be involved in spermatogenesis
• required for sperm development, possibly by participating in pre-mRNA splicing in the testis
• interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 & KHDRBS3

Structure

• contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• testis-specific
• expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids

Notes

• the RBMY1 proteins are encoded by strongly repeated regions of the Y chromosome, mostly within the AZFb region
• the exact number of functional copies is unclear & may vary between individuals
• some copies may represent pseudogenes
• the proteins are very similar, which gives their individual characterization difficult & most studies do not discriminate between the different members
• reported interactions with a RBMY1 protein may involve any number of or all of the RBMY1 proteins
• UniProt reference changed in database 2/2012

More general terms

• RNA-binding motif protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5940
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5940
• OMIM: https://mirror.omim.org/entry/400006
• UniProt: http://www.uniprot.org/uniprot/P0DJD3.html