protein sprouty homolog 4; Spry-4 (SPRY4)

Function

• suppresses the insulin receptor & EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras
• probably impairs the formation of GTP-Ras
• interacts with the C-terminus of TESK1

Structure

• the Cys-rich domain is responsible for the localization of the protein to membrane ruffles
• belongs to the sprouty family
• contains 1 SPR (sprouty) domain

Compartment

• cytoplasm, cell projection, ruffle membrane
• peripheral membrane protein; cytoplasmic side (putative)

Alternative splicing

named isoforms=2; A, C

More general terms

• sprouty homolog
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81848
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81848
• OMIM: https://mirror.omim.org/entry/607984
• UniProt: http://www.uniprot.org/uniprot/Q9C004.html