dual specificity testis-specific protein kinase 1; testicular protein kinase 1 (TESK1)

Function

• dual specificity protein kinase activity catalyzing autophosphorylation & phosphorylation of exogenous substrates onboth Set/Thr & Tyr
• probably plays a central role at & after the meiotic phase of spermatogenesis
• activated by autophosphorylation on Ser-220
• kinase activity is inhibited by SPRED1 (putative)
• autophosphorylated on Ser & Tyr
• interacts with TAOK2; leading to inhibit TAOK2 activity
• interacts with SPRED1; leading to inhibit activity (
• interacts with SPRY4

ATP + a protein = ADP + a phosphoprotein

Cofactor: Mg+2, Mn+2 (putative)

Structure

• the extracatalytic C-terminal part is highly rich in Pro
• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family
• contains 1 protein kinase domain

More general terms

• testicular protein kinase (testis-specific protein kinase)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7016
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7016
• OMIM: https://mirror.omim.org/entry/601782
• UniProt: http://www.uniprot.org/uniprot/Q15569.html