carbohydrate sulfotransferase 7; chondroitin 6-sulfotransferase 2; C6ST-2; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; GST-5; N-acetylglucosamine 6-O-sulfotransferase 4; GlcNAc6ST-4; Gn6st-4 (CHST7)

Function

• catalyzes transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues
• preferentially acts on mannose-linked GlcNAc
• also able to catalyze transfer of sulfate to position 6 of the N-acetylgalactosamine (galNAc) residue of chondroitin
• also acts on core 2 mucin-type oligosaccharide & N-acetyllactosamine oligomer with a lower efficiency
• has weak or no activity toward keratan sulfate & oligosaccharides containing the galbeta1-4GlcNAc
• catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl galNAc

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate

Structure

• belongs to the sulfotransferase 1 family gal/GlcNAc/galNAc subfamily

Compartment

• Golgi membrane
• single-pass type 2 membrane protein (putative)

Expression

• widely expressed
• expressed in heart, spleen, liver & ovary > brain, placenta, thyroid, spinal cord & peripheral blood leukocytes
• not expressed in adult skin

More general terms

• carbohydrate sulfotransferase (CHST)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56548
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56548
• OMIM: https://mirror.omim.org/entry/300375
• UniProt: http://www.uniprot.org/uniprot/Q9NS84.html