carbohydrate sulfotransferase 5; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha; GST4-alpha; intestinal N-acetylglucosamine-6-O-sulfotransferase; I-GlcNAc6ST; intestinal GlcNAc-6-sulfotransferase; hIGn6ST; N-acetylglucosamine 6-O-sulfotransferase 3; GlcNAc6ST-3; Gn6st-3 (CHST5)

Function

• catalyzes transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues & O-linked sugars of mucin-type acceptors
• acts on the non-reducing terminal GlcNAc of short carbohydrate substrates
• it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures
• has no activity toward keratan
• not involved in generating high endothelial venule-expressed ligands for L-selectin
• substrate specificity may be influenced by its subcellular location

Structure

• belongs to the sulfotransferase 1 family gal/GlcNAc/galNAc subfamily

Compartment

• Golgi membrane
• single-pass type 2 membrane protein (probable)
• Golgi membrane, early secretory pathway

Alternative splicing

named isoforms=2

Expression

• predominantly expressed in small intestine & colon
• weakly expressed in lymphocytes
• not expressed in other tissues

Pathology

• down-regulated in colon adenocarcinomas

More general terms

• carbohydrate sulfotransferase (CHST)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23563
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23563
• OMIM: https://mirror.omim.org/entry/604817
• UniProt: http://www.uniprot.org/uniprot/Q9GZS9.html