mitochondrial import receptor subunit TOM34 homolog; translocase of outer membrane 34 kD subunit (TOMM34, URCC3)

Function

• import of protein precursors into the mitochondria
• component of mitochondrial receptor complex
• binds mature portion of mitochondrial precursor proteins
• interacts with cellular components
• weak ATPase activity
• chaperone-like protein (putative)
  • helps to keep newly synthesized precursors in an unfolded import compatible state
• interacts with HSP90A, VCP, ATP6M, KIAA0665, AMPK, DMAP1

Structure

• belongs to the Tom34 family
• contains 6 TPR repeats

Compartment

• mitochondrial outer membrane
• peripheral membrane, cytoplasmic side

Expression

ubiquitous

More general terms

• mitochondrial membrane protein
• phosphoprotein

Additional terms

• mitochondrial receptor complex; preprotein translocase complex; TOM complex

Component of

• mitochondrial receptor complex; preprotein translocase complex; TOM complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10953
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10953
• OMIM: https://mirror.omim.org/entry/616049
• UniProt: http://www.uniprot.org/uniprot/Q15785.html