amiloride-sensitive Na+ channel subunit alpha; epithelial Na+ channel subunit alpha; alpha-ENaC; SCNEA; nonvoltage-gated Na+ channel 1 subunit alpha; alpha-NaCH (SCNN1A, SCNN1)

Function

• Na+ permeable non-voltage-sensitive ion channel alpha subunit
• interacts with WW domains of NEDD4, NEDD4L, WWP1, WWP2
• ubiquitinated; this targets individual subunits for endocytosis & proteasome-mediated degradation (putative)

Structure

• belongs to the amiloride-sensitive Na+ channel family

Compartment

• apical cell membrane; multi-pass membrane protein
• apical membrane of epithelial cells Alternate splicing: 5 alternate splice forms

Expression

• highly expressed in lung & kidney
• intermediate levels in pancreas & liver
• low levels in heart & placenta
• induced by aldosterone Pathology:
• mutations associated with:
• autosomal recessive pseudohypoaldosteronism type 1 (PHA1)

More general terms

• plasma membrane protein
• amiloride sensitive Na+ channel subunit

Component of

• amiloride-sensitive Na+ channel or lung Na+ channel

Database

• UniProt: http://www.uniprot.org/uniprot/P37088.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6337
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6337
• OMIM: https://mirror.omim.org/entry/264350
• OMIM: https://mirror.omim.org/entry/600228