natural cytotoxicity triggering receptor 3; activating natural killer receptor p30; natural killer cell p30-related protein; NK-p30; NKp30; CD337 (NCR3, 1C7, LY117)

Function

• cytotoxicity-activating receptor
• may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis
• interacts with CD3Z

Structure

• belongs to the natural cytotoxicity receptor (NCR) family
• contains 1 Ig-like (immunoglobulin-like) domain

Compartment

• cell membrane; single-pass type 1 membrane protein (putative)

Alternative splicing

named isoforms=6

Expression

• selectively expressed by all resting & activated NK cells
• weakly expressed in spleen

Polymorphism

• polymorphism in NCR3 is associated with mild suceptibility to malaria

More general terms

• natural cytotoxicity triggering receptor
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=259197
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:259197
• OMIM: https://mirror.omim.org/entry/609148
• OMIM: https://mirror.omim.org/entry/611550
• UniProt: http://www.uniprot.org/uniprot/O14931.html