relaxin receptor 2; leucine-rich repeat-containing G protein-coupled receptor 8; G protein-coupled receptor affecting testicular descent (LGR8, GREAT, RXFP2)

Function

• receptor for relaxin
• activity is mediated by Gs proteins leading to stimulation of adenylate cyclase & an increase of cAMP
• may also be a receptor for Leydig insulin-like peptide (INSL3)

Structure

• belongs to the G-protein coupled receptor 1 family
• contains 1 LDL-receptor class A domain
• contains 10 LRR repeats (leucine-rich repeats)

Compartment

cell membrane

Expression

• expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells & bone marrow

Pathology

• defects in RXFP2 are a cause of cryptorchidism

Notes

uncertain whether Met-1 or Met-18 is the initiator

More general terms

• leucine-rich repeat-containing G protein-coupled receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1220
• OMIM: https://mirror.omim.org/entry/606655
• OMIM: https://mirror.omim.org/entry/219050
• UniProt: http://www.uniprot.org/uniprot/Q8WXD0.html