taste receptor, type 2, member 16 (T2R16, TAS2R16)

Function

• perception of bitterness
• gustducin-linked
• bitter taste receptor for phytonutrient beta glucopyranosides
  • some of which are toxic
  • some of which may lower risk of cancer &/or cardiovascular disease
• stimulates alpha gustducin (putative)
• PLC-beta-2
• gating of TRPM5

Structure

belongs to the G-protein coupled receptor T2R family

Compartment

membrane

Expression

• expressed in subsets of taste receptor cells of the tongue & palate epithelium, exclusively in gustducin-positive cells

Polymorphism

• Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism

More general terms

• taste receptor, type 2

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5083
• OMIM: https://mirror.omim.org/entry/103780
• OMIM: https://mirror.omim.org/entry/604867
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50833
• UniProt: http://www.uniprot.org/uniprot/Q9NYV7.html