cadherin-11; osteoblast cadherin; OB-cadherin; OSF-4 (CDH11)

Function

• cadherin

Structure

contains 5 cadherin domains

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

• expressed mainly in brain but also found in other tissues
• expressed in neuroblasts
• expressed in synovial cells

Pathology

• cadherin-11 on the surface of synovial cells triggers inflammation & synovial proliferation in rheumatoid arthritis (see pathology of rheumatoid arthritis)

More general terms

• cadherin
• glycoprotein

Additional terms

• osteoblast
• rheumatoid arthritis (RA)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1009
• OMIM: https://mirror.omim.org/entry/600023
• UniProt: http://www.uniprot.org/uniprot/P55287.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1009