vasopressin V1a receptor; V1aR; vascular/hepatic-type arginine vasopressin receptor; antidiuretic hormone receptor 1a; AVPR V1a (AVPR1A, AVPR1)

Function

• receptor for arginine vasopressin
• activity is mediated by G proteins which activate a phosphatidyl-inositol-Ca+2 second messenger system
• mediates glycogenolysis in liver & vascular smooth muscle contraction in smooth muscle
• involved in social behaviors, including affiliation & attachment

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A

Pathology

• one allelic variant has been linked to autism

More general terms

• vasopressin receptor or antidiuretic hormone [ADH] receptor
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:552
• OMIM: https://mirror.omim.org/entry/600821
• UniProt: http://www.uniprot.org/uniprot/P37288.html